Exploring the Lean Phenotype of Glutathione-Depleted Mice: Thiol, Amino Acid and Fatty Acid Profiles.
BackgroundAlthough reduced glutathione (rGSH) is decreased in obese mice and humans, block ds durga hand soap of GSH synthesis by buthionine sulfoximine (BSO) results in a lean, insulin-sensitive phenotype.Data is lacking about the effect of BSO on GSH precursors, cysteine and glutamate.Plasma total cysteine (tCys) is positively associated with ste